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Regulation of store-operated Ca2+ entry during the cell cycle
Cytoplasmic Ca2+ signals are central to numerous cell physiological processes, including cellular proliferation. Historically, much of the research effort in this area has focused on the role of Ca2+ signals in cell-cycle progression. It is becoming clear, however, that the relationship between Ca2+ signaling and the cell cycle is a 'two-way street'. Specifically, Ca2+-signaling pathways are remodeled during M phase, leading to altered Ca2+ dynamics. Such remodeling probably better serves the large variety of functions that cells must perform during cell division compared with during interphase. This is clearly the case during oocyte meiosis, because remodeling of Ca2+ signals partially defines the competence of the egg to activate at fertilization. Store-operated Ca2+ entry (SOCE) is a ubiquitous Ca2+-signaling pathway that is regulated during M phase. In this Commentary, we discuss the latest advances in our understanding of how SOCE is regulated during cell division.
Author(s): Arredouani, A (Arredouani, Abdelilah); Yu, F (Yu, Fang); Sun, L (Sun, Lu); Machaca, K (Machaca, Khaled)
Source: JOURNAL OF CELL SCIENCE, 123 (13): 2155-2162 JUL 1 2010
Language: English
Document Type: Article
Author Keywords: Calcium signaling; Cell division; Store-operated Ca2+ entry
KeyWords Plus: XENOPUS OOCYTE MATURATION; NUCLEAR-ENVELOPE BREAKDOWN; SEA-URCHIN EMBRYOS; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS; CORTICAL ENDOPLASMIC-RETICULUM; STROMAL INTERACTION MOLECULE-1; CAPACITATIVE CALCIUM-ENTRY; GERMINAL VESICLE BREAKDOWN; MITOTIC HELA-CELLS; PLASMA-MEMBRANE
Addresses: [Arredouani, Abdelilah; Yu, Fang; Sun, Lu; Machaca, Khaled] Qatar Fdn, WCMC Q, Dept Physiol & Biophys, Doha, Qatar
Reprint Address: Machaca, K, Qatar Fdn, WCMC Q, Dept Physiol & Biophys, POB 24144, Doha, Qatar
Funding Agency: National Institutes of Health - Qatar National Research Fund
Publisher: COMPANY OF BIOLOGISTS LTD
Publisher Address: BIDDER BUILDING CAMBRIDGE COMMERCIAL PARK COWLEY RD, CAMBRIDGE CB4 4DL, CAMBS, ENGLAND
ISSN: 0021-9533
29-char Source Abbrev.: J CELL SCI
ISO Source Abbrev.: J. Cell Sci.
Subject Category: Cell Biology
ISI Document Delivery No.: 611WU
Author(s): Arredouani, A (Arredouani, Abdelilah); Yu, F (Yu, Fang); Sun, L (Sun, Lu); Machaca, K (Machaca, Khaled)
Source: JOURNAL OF CELL SCIENCE, 123 (13): 2155-2162 JUL 1 2010
Language: English
Document Type: Article
Author Keywords: Calcium signaling; Cell division; Store-operated Ca2+ entry
KeyWords Plus: XENOPUS OOCYTE MATURATION; NUCLEAR-ENVELOPE BREAKDOWN; SEA-URCHIN EMBRYOS; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS; CORTICAL ENDOPLASMIC-RETICULUM; STROMAL INTERACTION MOLECULE-1; CAPACITATIVE CALCIUM-ENTRY; GERMINAL VESICLE BREAKDOWN; MITOTIC HELA-CELLS; PLASMA-MEMBRANE
Addresses: [Arredouani, Abdelilah; Yu, Fang; Sun, Lu; Machaca, Khaled] Qatar Fdn, WCMC Q, Dept Physiol & Biophys, Doha, Qatar
Reprint Address: Machaca, K, Qatar Fdn, WCMC Q, Dept Physiol & Biophys, POB 24144, Doha, Qatar
Funding Agency: National Institutes of Health - Qatar National Research Fund
Publisher: COMPANY OF BIOLOGISTS LTD
Publisher Address: BIDDER BUILDING CAMBRIDGE COMMERCIAL PARK COWLEY RD, CAMBRIDGE CB4 4DL, CAMBS, ENGLAND
ISSN: 0021-9533
29-char Source Abbrev.: J CELL SCI
ISO Source Abbrev.: J. Cell Sci.
Subject Category: Cell Biology
ISI Document Delivery No.: 611WU
